High Frontier by Phil Eklund, to be released by Sierra Madre Games, bills itself as “the most realistic tabletop rocket game ever made”.  By which they mean tabletop game, not tabletop rockets.

And by which they mean that the game focuses around the anticipated economics, politics, and physics involved in flinging rockets about the Solar System. It is currently available for pre-order at a discount.

You can see a gist of the game play and rules here, and a blog with tons of pictures and information here.